Employing EEG, behavioral measures and subjective evaluation our group investigates potentially clinically applicable brain responses - both during the resting-state and in response to external sensory stimulation. We evaluate how subjects' traits and states, task they perform and stimulation we use affects brain activity.
We use various approaches (i.e. classical P300, P50, Go/NoGo, MMN), however, our special focus is on the brains' ability to entrain measured as steady-state responses (SSRs): we evaluate brain's entrainment to external stimulation (auditory, visual, somatosensory ) and factors that modulate it.
This knowledge is important in order to objectively collect data and interpret obtained results both in healthy and diseased populations.

 

Group members:

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Dr. Inga Griškova-Bulanova, Research Professor

 av

Dr. Aleksandras Voicikas, Junior Assistant

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Sigita Mėlynytė,
PhD Student

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Evaldas Pipinis,
PhD Student

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Vykinta Parčiauskaite,
PhD Student

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Aida Grabauskaitė,
PhD Student

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Dovilė Šimkutė,
PhD Student

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Povilas Tarailis,
PhD Student

Contacts

Dr. Inga Griskova-Bulanova, inga.griskova-bolanova[eta]gf.vu.lt

Collaboration

In collaboration with Drs. T. Palenicek, M. Brunovsky and many young researchers at the National Institute of Mental Health (Klecany, Czech Republic) we evaluate effects of psychedelic drugs on brain's ability to follow periodic stimulation.  

In collaboration with Drs. M. Binder and U. Gorska at Jagiellonian University (Krakow, Poland) we evaluate the potential use of auditory SSR as a biomarker of consciousness level in disorders of consciousness.

In collaboration with Drs. A. Dores and F. Barbosa at Porto University (Porto, Portugal) we elaborate ways to assess brain activity specific to gaming/gambling.

In collaboration with Drs. Y. Naruse and Y. Yokota at  Center for Information and Neural Networks  (Osaka, Japan) we develop neurobiofeedback system.

In collaboration with a team from Latvian Academy of Music (Riga, Latvia) and a team from the National Sun Yat-sen University (Kaohsiung, Taiwan) we develop a music-based biofeedback system.

In collaboration with Dr. J. Bjekic at University of Belgrade (Belgrade, Serbia) we investigate brain stimulation induced changes in EEG.

In collaboration with Dr. C. Saavedra from Valparaiso University (Valparaiso, Chile)  we elaborate novel indexes for evaluation of auditory SSRs.   

In collaboration with Dr. G.Wang from Auckland University of Technology (Auckland, New Zealand) we investigate changes in brain electrical activity occurring in various addictions. 

In collaboration with Dr. J. Burkauskas at the Labaratory of Behavioral Medicine of Neuroscience institute of Lithuanian University of Health Sciences (Palanga, Lithuania) we evaluate brain changes during associated with excessive internet use.

 

Former:

In collaboration with Dr. C. Pacoret at the University of Geneva (Geneva, Switzerland) we seek to explain the generation of ASSRs. 

In collaboration with Prof. T. Koenig at University Hospital of Psychiatry (Bern, Switzerland)  we evaluate the potential alternative ways to evaluate auditory SSRs. 

In collaboration with Dr. K. Dapsys at Republican Vilnius Psychiatric Hospital (Vilnius, Lithuania) we evaluate entrainment abilities as a biomarker for schizophrenia treatment response.  

In collaboration with Prof. O. Ruksenas and Dr. R. Griksiene at Vilnius University we perform evaluation of hormonal status on potentially clinically applicable brain responses.  

In collaboration with Dr. M. Korostenskaja at Florida Childrens' Hospital (Orlando, USA) we evaluate anatomical and functional correlates of brain's ability to entrain.

Projects

2020-2021 Research project  "Individual gamma frequency-based neurofeedback: development and implementation study" P-LJB-20-4,  Research Council of Lithuania within the framework of collaboration with Japan (Project Leader I. Griskova-Bulanova, participants Dr. A.Voicikas, Dr. V. Jurkuvenas, E. Pipinis)

2020-2021 Research project “Determinants of quality of life in Lithuanian students: problematic usage of the Internet and neuropsychological profile”, Research Council of Lithuania within the framework of  National Programme “Welfare Society” (Co-Principal Investigator I. Griskova-Bulanova, participant D. Simkute)

2020-2022 Research project "Steady-state EEG response to gamma-range auditory stimulation: effects of brain arousal", Project number 2018/31/b/hs6/03920, Polish National Science Centre (Researchers I. Griskova-Bulanova, E. Pipinis)  

2020 International Brain Research Organization Pan European Regional Committee In Europe Short Stay Grant (E. Pipinis) 

2019 Grants in the framework “Development of scientific competence of scientists, other researchers, students through practical scientific activities” (Nr. 9.3.3-LMT-K-712) from the Research Council of Lithuania (Project participant I.Griškova-Bulanova)

2019-2021 Research project “Brain-Computer Music Interfacing for Embodied Musical Interaction”; Parties: Latvia, Taiwan (Project Leader I.Griškova-Bulanova; Project researchers A.Voicikas, E.Pipinis, P.Tarailis)

2019-2023 COST action “The neural architecture of consciousness” (Project Leader I.Griškova-Bulanova; Project researchers E.Pipinis, P.Tarailis, A. Grabauskaitė)

2018 - 2022 PhD project “Effect of the problematic internet usage on brain activity: an EEG study” (Project Leader I.Griškova-Bulanova; Project participant D. Šimkutė)

2018-2022 COST action “European network for problematic internet usage” (Project Leader I.Griškova-Bulanova; Project researchers D. Šimkutė, P.Tarailis)

2018 Host for International Brain Research Organization Pan European Regional Committee InEurope Short Stay Grant (Visiting researcher V.Viktorin)

2018 Grants in the framework “Development of scientific competence of scientists, other researchers, students through practical scientific activities” (Nr. 9.3.3-LMT-K-712) from the Research Council of Lithuania (Project participants I.Griškova-Bulanova, Y.Naruse)

2018 Grants in the framework “The increase of internationality of Lithuanian science - development of  R & D relationships (LINO LT)” (Nr. 09.3.3-ESFA-V-711-04-0001) from the Research Council of Lithuania (Project participants I.Griškova-Bulanova, A.Voicikas, E.Pipinis, T.Palenicek, M.Brunovsky)

2018-2019 Research project “New EEG Clustering Methods for Pre-clinical and Clinical Applications” funded by Chilean funding agency Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) (Project Leader I. Griskova-Bulanova; Project Participants A. Voicikas,  E. Pipinis).

2016-2021 PhD project „ Brain ability to entrain measured with EEG: research of functional behavioral correlates“ (Project Leader I. Griskova-Bulanova; Project Participant V. Parciauskaite).

2016.01-07 Institutional partnership project “State-dependent information processing: implementation of electrical neuroimaging approach in Lithuania” in collaboration with University of Geneva and University Hospital of Psychiatry Bern, CH-3-ŠMM-02/03 from the Research Council of Lithuania within the Lithuanian-Swiss programme „Research and development“ (Project Leader I. Griskova-Bulanova, Project Participants A.Voicikas, S. Melynyte, E. Pipinis).

2015-2020 PhD project „Brain electrical responses to chirp stimulation: effect of task and changes in neuropsychiatric disorders“(Project Leader I. Griskova-Bulanova; Project Participant E. Pipinis).

2014-2019 PhD project „Generation mechanisms of brain electrical steady-state responses“, (Project Leader I. Griskova-Bulanova; Project Participant A. Voicikas).

2014-2017 Research project „Normative data set of electromagnetic brain signatures“ funded by Florida Childrens’ Hospital; PIs M. Korostenskaja, E. Castillo, Co-Investigator I. Griskova-Bulanova.

2014-2016 Research project “Treatment-resistant schizophrenia: identification of electrophysiological markers” MIP-009/2014 form the Research Council of Lithuania (PI I. Griskova-Bulanova; Project participants S. Melynyte and A. Voicikas).

2014-2015 Research project “Modulation of Electrophysiological Correlates of Response Inhibition By Female Sex Hormones: Implications for Brain Disorders” supported by World Federation of Scientists (Project Participant I. Griskova-Bulanova).

2013-2015 Research project “EegSchCt: Electrophysiological study of brain activity in schizophrenic patients during two different visuospatial "Clock tasks" funded by Swiss Granting agency (Sciex-NMSch) funded project; (Co-Investigator I. Griskova-Bulanova).

2012-2013 Research project “Research of dependence of Auditory Evoked Potentials on Psychological and physiological state” supported by Lithuanian Academy of Sciences (PI I.Griskova-Bulanova).

2012-2014 Grants in the framework of "Promotion of Student Scientific Activities" (VP1-3.1-ŠMM-01-V-02-003) from the Research Council of Lithuania (PI I.Griskova-Bulanova).

Awards

Dr. Inga Griškova-Bulanova, Rector's Award for Scientific Contribution, Vilnius University, 2016

Publications

ISI Journals:

Binder M, Gorska U, Pipinis E, Voicikas A, Griskova-Bulanova I. (2020) Auditory steady-state response to chirp-modulated tones: a pilot study in patients with disorders of consciousness. Neuroimage Clinical (accepted)

Parciauskaite V, Voicikas A, Jurkuvenas V, Tarailis P, Kraulaids M, Pipinis E, Griskova-Bulanova I. (2019) 40-Hz auditory steady-state responses and the complex information processing: an exploratory study in healthy young males. Plos One v.14(10)

Melynyte S, Wang GY, & Griskova-Bulanova I. (2018). Gender effects on auditory P300: A systematic review. International Journal of Psychophysiology 133:55-65

Pipinis E, Voicikas A, Griskova-Bulanova I. (2018) Low and high gamma auditory steady-states in response to 440 Hz carrier chirp-modulated tones show no signs of attentional modulation. Neuroscience Letters 678:104-109

Wang G, Griskova-Bulanova I (2018) Electrophysiological activity is associated with vulnerability of problematic Internet use in non-clinical population. Addictive Behaviors 84:33-39

Griskova-Bulanova I, Pipinis E, Voicikas A, Koenig T. (2018) Global field synchronization of 40Hz auditory steady-state response: does it change with attentional demands? Neuroscience Letters 674:127-131

Bravermanova A, Viktorinova M, Tyls F, Novak T, Androvicova R,  Korcak J, Horacek J, Griskova-Bulanova I, Balikova M, Danielova D, Vlcek P, Brunovsky M, Mohr P, Palenicek T. (2018) Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing - study on P300 and mismatch negativity in healthy volunteers, Psychopharmacology 235(2):491-503

Melynyte S, Pipinis E, Genyte V, Voicikas A, Rihs T, Griskova-Bulanova T. 40Hz auditory steady-state response: the impact of handedness and gender. (2018) Brain Topography 31:419-429.  

Griskova-Bulanova I, Dapsys K, Melynyte S, Voicikas A, Maciulis V, Andruskevicius S, Korostenskaja M. (2018) 40 Hz auditory steady-state response in schizophrenia: Sensitivity to stimulation type (clicks versus flutter amplitude-modulated tones), Neuroscience Letters 662:152-157.

Baranauskas M, Grabauskaitė A, Griškova-Bulanova I. (2017). Brain responses and self-reported indices of interoception: Heartbeat evoked potentials are inversely associated with worrying about body sensations, Physiology & Behavior 180:1-7.

Dankinas D, Melynyte S, Siurkute A, Dapsys K. (2017) Pathological Imitative Behavior and Response Preparation in Schizophrenia. Arch Clin Neuropsychol 13(5):1-8.

Binder M, Gorska U, Griskova-Bulanova I. (2017) 40 Hz auditory steady-state responses in patients with disorders of consciousness: correlation between CRS-R score and phase-locking index. Clinical Neurophysiology 128(5):799-806.

Melynyte S, Ruksenas O, Griskova-Bulanova I. (2017) Sex differences in equiprobable auditory Go/NoGo task: effects on N2 and P3. Experimental Brain Research 235(5):1565-1574.

Grabauskaite A, Baranauskas M, Griskova-Bulanova I. (2017) Interoception and gender: What aspects should we pay attention to? Consciousness and Cognition 48:129–137.

Pipinis E, Melynyte S, Koenig T, Jarutyte L, Linkenkaer-Hansen K, Ruksenas O, Griskova-Bulanova I. (2017) Association Between Resting-State Microstates and Ratings on the Amsterdam Resting-State Questionnaire. Brain Topography 30(2), 245-248

Voicikas A, Niciute I, Ruksenas O, Griskova-Bulanova I. (2016) Effect of attention on 40Hz auditory steady-state response depends on the stimulation type: flutter amplitude modulated tones versus clicks. Neuroscience Letters 629:215-220

Griskova-Bulanova I, Griksiene R, Voicikas A, Ruksenas O. (2016) Go and NoGo: modulation of electrophysiological correlates by female sex steroid hormones . Psychopharmacology 233(13):2607-15

Griskova-Bulanova I, Hubl D, van Swam C, Dierks T, Koenig T. (2016) Early- and late-latency gamma auditory steady-state response in schizophrenia during closed eyes: does hallucination status matter? Clinical Neurophysiology 127(5): 2214-21

Antonova I, van Swam C, Hubl D, Dierks T, Griskova-Bulanova I, Koenig T. (2016) Reaction time in a visual 4-choice reaction time task: ERP effects of response anticipation, hemispheric involvement, and individual traits of attention. Brain Topography 29(4):491-505

Korostenskaja M, Ruksenas O, Pipinis E, Griskova-Bulanova I. (2016). Phase-locking index and power of 40-Hz auditory steady-state response are not related to major personality trait dimensions. Experimental Brain Research 234(3):711-9

Antonova I, Bänninger A, Dierks T, Griskova-Bulanova I, Koenig T, Kohler A. (2015) Differential recruitment of brain networks during visuospatial and color processing: evidence from ERP microstates. Neuroscience 305:128-38.

Dankinas D, Parciauskaite V, Dapsys K. (2015). Intra-individual reaction time variability and response preparation: an EEG study. Acta neurobiologiae experimentalis 75, 462-8.

Noreika D, Griskova-Bulanova I, Alaburda A, Baranauskas M, Griksiene R. (2014) Progesterone and mental rotation task: is there any effect? BioMed Research International ID741758

Griskova-Bulanova I, Griksiene R, Korostenskaja M, Ruksenas O. (2014). 40Hz auditory steady-state response in females: when is it better to entrain? Acta Neurobiologiae Experimentalis 74(1):91-7.

Griskova-Bulanova I, Dapsys K, Maciulis V. (2013). Does brain ability to synchronize with 40Hz auditory stimulation change with age? Acta Neurobiologiae Experimentalis 73(4):564-70.

Griskova-Bulanova I, Korostenskaja M. (2013). Neurophysiological markers of brain's ability to entrain and to detect change: methodological considerations. Proceedings of the 11th international conference on medical physics. ISSN 1822-5721. 79-84.

Griskova-Bulanova I, Dapsys K, Maciulis V, Arnfred SM. (2013). Closed eyes condition increases auditory brain responses in schizophrenia. Psychiatry Research: Neuroimaging 211(2):183-5.

Griskova-Bulanova I, Ruksenas O, Dapsys K, Maciulis V, Arnfred SM. (2012). P50 potential-associated gamma band activity: modulation by distraction. Acta Neurobiologiae Experimentalis 72:102-9.

Griskova-Bulanova I, Paskevic J, Dapsys K, Maciulis V, Ruksenas O, Arnfred SM. (2011). The level of arousal modulates P50 peak amplitude. Neuroscience Letters 499(3):204-7.

Griskova-Bulanova I, Ruksenas O, Dapsys K, Maciulis V, Arnfred SM. (2011). Distraction task rather than focal attention modulates gamma activity associated with auditory steady-state responses. Clinical Neurophysiology 122(8):1541-8

Griskova I, Morup M, Parnas J, Ruksenas O, Arnfred SM. (2009). Two discrete components of the 20 Hz steady-state response are distinguished through the modulation of activation level. Clinical Neurophysiology 120(5):904-909.

Griskova I, Morup M, Parnas J, Ruksenas O, Arnfred SM. (2007). The amplitude and phase precision of 40 Hz auditory steady-state response depend on the level of arousal. Experimental Brain Research 183(1):133-138.

Griskova I, Ruksenas O, Dapsys K, Herpertz S, Hoppner J. (2007). The effects of 10 Hz repetitive transcranial magnetic stimulation on resting EEG power spectrum in healthy subjects. Neuroscience Letters, 419(2): 162-167.

Griskova I, Dapsys K, Andruskevicius S, Ruksenas O. (2005). Does electroconvulsive therapy (ECT) affect cognitive components of auditory evoked P300? Acta Neurobiologiae Experimentalis, 65:73-77.

Another journals:

Dankinas D, Mėlynytė S, Šiurkutė A, Dapšys K. Response preparation and intra-individual reaction time variability in schizophrenia. Acta Medica Lituanica. 2016; 23(1):35-42

Griskova-Bulanova I. (2015) Application of transcranial magnetic stimulation for diagnosis, treatment and functional mapping in pediatric epilepsy. Journal of Pediatric Neurology, 4: 165-173.

Korostenskaja M, Griskova-Bulanova I, Lee KH, Chen PC, Kleineshay TS, Cook JC, Schaal AE, Castillo EM. (2014). Contributions of neuroimaging to understand childhood epileptic encephalopathies. Journal of Pediatric Neurology 3, 131-156.

Griškova-Bulanova I, Kazlauskienė N. (2013). Some effects of aging on auditory event-related potentials. Neurologijos seminarai, 17 (56), 132-137.

Griškova-Bulanova I. Non-invasive evaluation of electrical brain activity: effects of nonmedicative treatment and subject‘s state. (2013). Acta Medica Lituanica, 20 (1), 27-31.

Dapšys K, Griškova-Bulanova I, Kaukėnas R, Šiurkutė A, Mačiulis V. (2012). Effects of electroconvulsive therapy on P300 potential in affective and schizophrenia spectrum disorders. Sveikatos mokslai,1, 82-88.

Veršinskas R, Griškova I, Razgauskas E, Račiukaitytė K, Jankauskas D, Jocys Č, Motuzas R, Marksienė E, Vaičiulis K, Žukauskas G, Liausėdas A. (2010). Agression prevalence among different human groups in Lithuania. Sveikatos mokslai, 2, 3034-3046.

Griškova I, Rukšėnas O. Neinvaziniai smegenų elektrinių atsakų analizės metodai. 5os mokslinės konferencijos „Mokslas Gamtos mokslų fakultete“ konferencijos medžiaga, 2008 p.46-56.

Griskova I, Arnfred S. (2008). An electrophysiological approach to investigations of sensory dysfunction in schizophrenia. Poiesis and Praxis, DOI 10.1007/s10202-008-0063-1

Griskova I, Hoppner J, Ruksenas O, Dapsys K. (2006). Transcranial magnetic stimulation: the method and application. Medicina (Kaunas), 42(10):798-804.

Griskova I, Dapsys K, Ruksenas O, Kaukenas R, Maciulis V. (2005). Association between changes of ERPs and physiological response to ECT treatment: a pilot study. Laboratorinė Medicina, 4(28):3-6.

Griskova I, Dapsys K, Ruksenas O, Siurkute A, Maciulis V. (2005). Effects of electroconvulsive therapy on auditory information processing in treatment-resistant schizophrenic patients: P300 potential study. Laboratorinė Medicina, 3(27):14-17.

Griskova I, Buchmann J, Ruksenas O, Dapsys K, Hoppner J. (2005). Application of transcranial magnetic stimulation in motor cortex excitability studies: brief review. Laboratorinė Medicina, 4(28):11-16.

Griskova I, Dapsys K, Ruksenas O, Korostenskaja M. (2004). Mechanisms of action of electroconvulsive therapy. Medicinos teorija ir praktika, 1(37):90-91.

Book chapters:

1) Griskova I. Changes assessed by EEG after TMS. In “Repetitive transcranial magnetic stimulation (rTMS) in the treatment and rehabilitation of central nervous diseases”. Editor Mally J. Budapest, Eurobridge Co, 2009, p.77-93.

2) Griskova I. In “Sleep and anxiety”. Editor Verbitsky EV. Rostov-on-Don, SSC RAS Publishers, 2008, p. 222-231. (in russian).