We investigate mechanisms of visual system using electrophysiological approach and rodent models:

- By registering visual evoked potentials from rat visual cortex and local field potentials from various subcortical nuclei we investigate effect of various biologically active compounds, like alcohol, on activity of neurons from visual cortex and how these effects correlate with animals age, sex, duration and quantity of compound usage;

- By registering electroretinograms from the mouse eye we investigate effectiveness of newly synthetized compounds in treatment of eye diseases, like retinitis pigmentosa.

 

 

Group members

  • Prof. Osvaldas Rukšėnas
  • Dr. Rokas Buišas
  • PhD students: Redas Dulinskas, Tomas Paulauskas

 

Collaborators

Institute of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany

JSC Profarma, Lithuania

Awards

Lithuanian Science Award, 2011

Projects

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Publications

"Temporal structure of neuronal responses and its relation to visual neuron tuning characteristics"- O.Ruksenas, V.Vanagas, J.Ketleris, R.Satinskas, A.Purtulyte// Experimental Biology (Vilnius)- 1991.- N2(6).- P.26-38.

"Sympathectomy and d-tubocurarinchloride in immobilisation of the eye in the cat"- O.Ruksenas, R.Satinskas//Scand. J. Lab. Anim. Sci. 1996, No1, v.23, P.425-430.

”Spatial summation and center-surround antagonism in the receptive field of single units in the dorsal lateral geniculate nucleus of cat. Comparison with retinal input”- O.Ruksenas, I.T. Fjeld, P.Heggelund// Visual Neuroscience, 2000, 17, 855-870.

“Brainstem modulation of visual response properties of single cells in the dorsal lateral geniculate nucleus of cat”- I.T. Fjeld, O. Ruksenas, P. Heggelund// J.Physiol. (Lond.) 2002, Nr. 543(2), P. 541-554.

“Analysis of bursting activity in phasic and tonic components of dLGN relay cells responses” - Sigita Augustinaite, Osvaldas Ruksenas// Biologija, 2004, 4:19-25.

„Dynamics of spatial resolution of single units in the lateral geniculate nucleus of cat during brief visual stimulation“ Ruksenas O., Bulatov A., Heggelund P. // J Neurophysiol. 2007, 97(2), P.1445-56

Jurkus, P., Ruksenas O., Heggelund P. Temporally advanced dynamic change of receptive field of lateral geniculate neurons during brief visual stimulation: effects of brainstem peribrachial stimulation// Neuroscience, 2013, 242:85-96.

"Effect of ethanol on the visual-evoked potential in rat: dynamics of ON and OFF responses" Dulinskas R, Buisas R, Vengeliene V, Ruksenas O. Acta Neurobiol. 2017;77(2):190-197.